各种组织学类型的局部晚期直肠癌对新辅助多模式疗法的反应
Muhammad Sohaib Nadeem1, Ujala Ali2, Amjad Khan3
1Department of Radiation Oncology, Combined Military Hospital, Rawalpindi, Pakistan.
JPMA. The Journal of the Pakistan Medical Association
|July 19, 2024
概括
新辅助化学辐射疗法在先进的直肠癌亚型中显示出不同的反应. 粘性和结环细胞变体显示出较少的瘤回归,这表明需要加强治疗策略.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 病理学 病理学 病理学
背景情况:
- 局部晚期直肠癌 (LARC) 需要有效的新辅助疗法来改善结果.
- 了解组织学亚型反应对于个性化治疗至关重要.
研究的目的:
- 评估不同组织学类型的局部晚期直肠癌对新辅助多模式治疗的反应.
- 在新辅助治疗后,在各种直肠癌亚型中比较瘤回归率.
主要方法:
- 108名LARC患者的回顾性队列研究 (2020-2021年).
- 新辅助疗法包括用capecitabine进行体积弧疗法 (45 Gy + 5.4 Gy提升).
- 盆腔MRI评估了反应;直肠癌回归度评估了组织学回归.
主要成果:
- 总体而言,59.3%的患者表现出瘤回归.
- 腺癌 (73.15%的患者) 的回归率为74.6%.
- 标签环细胞 (11.11%) 和粘膜变体 (15.74%) 的回归率较低 (83.3%和70.5%).
结论:
- 粘性和结环细胞直肠癌变体显示,在新辅助疗法后,瘤回归减少.
- 对于这些特定的组织学,可能需要加强或修改治疗.
- 对针对不同直肠癌亚型的定制新辅助策略进行进一步的研究是有必要的.
更多相关视频
12:45Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
Published on: February 12, 2022
5.6K
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
246
相关概念视频
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.