母亲AMPK通路的激活与子宫动脉血流和胎儿在缺氧期间的生长维护
Lorna G Moore1, Ramón A Lorca1, Diane L Gumina1,2
1Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
概括
高海拔怀孕会减少子宫动脉的血流和出生体重. 增加AMP激活蛋白激酶 (AMPK) 路径基因表达,特别是PRKAA1,与更好的子宫动脉功能和胎儿生长相关,可能减轻缺氧效应.
科学领域:
- 生殖生理学 生殖生理学
- 高度医学 高度医学
- 胎儿的发育 胎儿的发育
背景情况:
- 高海拔 (HA) 缺氧会损害子宫动脉 (UtA) 的血液流动,并降低怀孕期间的出生体重.
- AMP激活蛋白激酶 (AMPK) 激活表现出子宫胎盘血管扩张作用,可能抵消低氧诱导的出生体重减少.
研究的目的:
- 调查AMPK通路基因表达与在HA中母亲循环中的代谢物之间的关系.
- 确定AMPK通路活性与UtA血流和HA怀孕中出生体重维持的关联.
主要方法:
- 在HA (2,793米) 和低海拔 (LA; 1,640米) 的女性之间比较UtA直径,血流,出生体重和AMPK通路基因表达.
- 对PRKAA1基因表达与UtA参数和妊娠中期和晚期胎儿生物学的相关性分析.
主要成果:
- 与洛杉矶居民相比,HA居民的UtA直径较小,20周 UtA血流量较低,出生体重较低.
- 在第34周,HA女性显示上游和下游AMPK通路基因的表达减少.
- PRKAA1基因表达与UtA直径和血液流量 (20周在HA;34周在LA) 呈正相关,下游基因表达与胎儿生物识别和出生体重相关.
结论:
- 在HA怀孕中AMPK通路基因表达的减少可能导致UtA功能受损和胎儿生长.
- PRKAA1表达和UtA血流之间的积极相关性表明,在妊娠中期增强的AMPK激活灵敏度可能会减轻低氧对胎儿生长的有害影响.
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