较低的CD4计数预测在HIV第一线治疗期间过度体重增加
Andrew Hill1, Tamara Tovar Sanchez2, Eric Delaporte2
1University of Liverpool, Department of Pharmacology and Therapeutics, 70 Pembroke Place, Liverpool L69 3GF, Liverpool, UK.
The Journal of antimicrobial chemotherapy
|July 19, 2024
概括
抗逆转录病毒治疗可能会导致显著的体重增加,特别是在CD4计数较低的个体中. 诺福维尔二松胺和埃法维伦兹可能有助于抑制这种体重增加.
科学领域:
- 艾滋病毒/艾滋病研究研究
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- 体重增加是抗逆转录病毒治疗 (ART) 的常见副作用.
- 某些人群,包括女性,黑人以及基线CD4数量较低的人群,更容易受到感染.
- 特定的ART疗法,如诺福维尔二二醇 fumarate (TDF) 或 efavirenz (EFV),可以减轻这种体重增加.
研究的目的:
- 分析一线ART开始后的体重变化和肥胖发病率.
- 确定不同患者群体中体重增加和肥胖的预测因素.
主要方法:
- 来自三项主要临床试验 (ADVANCE,NAMSAL,WHRI001) 的数据汇总,涉及2242名参与者.
- 体重和体重指数 (BMI) 在96周被评估,并根据基线CD4计数进行分层.
- 使用多变量模型分析体重变化和发生肥胖 (BMI ≥30 kg/m2),调整了关键的人口和治疗变量.
主要成果:
- 所有治疗手臂从基线到96周的体重增加.
- 基线CD4计数<100细胞/毫米3与最高的平均体重增加 (+8.6公斤) 相关.
- 包括诺福维尔阿拉芬胺 (TAF) 的疗法,特别是TAF/emtricitabine (FTC) + dolutegravir (DTG),在基线CD4计数较低的人群中显示出更高肥胖率的趋势.
结论:
- 具有较低基线CD4计数的个体在ART启动时可能会经历相当大的"超标"体重增加.
- TAF/FTC + DTG疗法可能会增加这个脆弱群体的肥胖风险.
- TDF和EFV与体重增加较少有关,突出显示需要体重管理策略,特别是对于CD4计数较低的人来说.
更多相关视频
05:53Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
16.6K
07:10Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
Published on: January 7, 2019
15.7K
相关概念视频
01:29Pulmonary Tuberculosis I
228
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
228
01:10Retrovirus Life Cycles
45.8K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.8K
01:24Obesity
432
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
432
01:25Immunodeficiency Diseases
933
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
933