终潮控制与手动控制的吸入麻醉输送:一个随机控制的非劣质试验
Melissa D McCabe1, Guy de L Dear2, Matthew A Klopman3
1From the Department of Anesthesiology, Loma Linda University School of Medicine, Loma Linda, California.
Anesthesia and analgesia
|July 19, 2024
概括
终潮控制 (EtC) 系统提供精确的麻醉输送,匹配手动控制 (MC) 的性能. 与MC相比,EtC更有效地达到和维持目标麻醉剂和氧气度.
科学领域:
- 麻醉学 麻醉学
- 医疗器械 医疗器械
- 临床试验 临床试验
背景情况:
- 精确的麻醉输送对于患者的记忆丧失,止痛和不运动至关重要.
- 麻醉剂输送系统的手动调节是传统的,但可能不精确.
- 闭环系统提供了对麻醉剂度的自动控制.
研究的目的:
- 在Aisys CS 2麻醉机上评估终潮控制 (EtC) 系统的性能.
- 测试一个假设,即 EtC 麻醉的交付与手动控制 (MC) 不逊色.
主要方法:
- 在MASTER试验中,有210名成年患者随机接受ETC或MC麻醉.
- 通过比较EtAA和EtO2度保持在定义范围内的时间百分比来评估非劣质性.
- 二次结果包括响应时间,超标和准确性.
主要成果:
- 在98%的时间里,EtC保持了目标EtAA度在所需值的5%以内,而MC的度为45.7%.
- 在86.3%的时间里,EtC保持了EtO2的限制,而MC的时间为41%.
- EtC显示了更快的中位响应时间 (75s vs. 158s) 和较少的偏离目标EtAA.
结论:
- 该EtC系统实现并保持终潮麻醉剂 (EtAA) 和终潮氧气 (EtO2) 度不低于手动控制.
- EtC在麻醉药物输送中提供了更高的精度和更快的响应.
- 像EtC这样的自动化麻醉输送系统可以增强麻醉管理.
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