验证感染儿童器官功能障碍得分的表现:一个队列研究
Shaojun Li1,2, Tao Tan3, Jing Li2,4
1Emergency Department, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Intensive Care Unit, Children's Hospital of Chongqing Medical University, Chongqing, China.
PloS one
|July 19, 2024
概括
儿科SOFA (pSOFA) 和PELOD2得分有效预测感染儿童的医院死亡率. 建议使用pSOFA评分来评估儿科败血症中器官功能障碍.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 传染性疾病 传染性疾病
- 临床评分系统 临床评分系统
背景情况:
- 儿科败血症和严重感染是死亡的重要原因.
- 准确预测死亡率对于及时干预和资源分配至关重要.
- 存在几种评分模型,但它们在儿科群体中的表现需要验证.
研究的目的:
- 验证六种已建立的评分模型在怀疑或确诊感染的儿童中预测医院死亡率方面的性能.
- 为了比较不同评分系统的预测准确性和临床实用性.
主要方法:
- 一个单一中心的回顾性队列研究,涉及因感染入住儿科重症监护室 (PICU) 的儿科患者.
- 包括5356名患者,医院死亡率作为主要结局.
- 对六种评分模型的评估:适应年龄的pSOFA,SIRS,PELOD2,Sepsis-2,qSOFA和PMODS.
主要成果:
- 儿科序列器官衰竭评估 (pSOFA) 和儿科物流器官功能障碍-2 (PELOD2) 评分显示,与其他模型相比,优越的歧视能力.
- 校准分析显示,pSOFA和PELOD2.2的预测和观察死亡率之间有很好的一致性.
- 乳酸盐水平升高被确定为该队列中死亡的重要风险因素.
结论:
- 在pSOFA和PELOD2得分显示出优异的预测性表现,在感染的重症儿童的医院死亡率.
- 建议使用pSOFA评分作为评估儿科败血症急性器官功能障碍的最佳,临床可操作的工具.
- 乳酸盐水平升高与患有感染的儿科PICU患者死亡风险增加密切相关.
相关概念视频
01:26Factors Affecting the Risk of Infection
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
01:30Pneumonia III: Complications and Assessment
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...