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相关概念视频

Propagation of Action Potentials01:23

Propagation of Action Potentials

5.6K
The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
5.6K
Postsynaptic Potential (PSP)01:32

Postsynaptic Potential (PSP)

2.5K
Postsynaptic potential (PSP) refers to a change in the electrical potential of a neuron when neurotransmitters released by presynaptic neurons bind to postsynaptic receptors. This potential can either be excitatory, leading to depolarization and ultimately action potential generation, or inhibitory, leading to hyperpolarization and suppression of the postsynaptic neuron.
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...
2.5K
Action Potential: Phases of Stimulation01:28

Action Potential: Phases of Stimulation

5.4K
The action potential is a complex electrical event that occurs in excitable cells, such as neurons and muscle cells. It consists of several distinct phases, each with specific characteristics.
Resting Phase:
In this phase, the cell's membrane is at its resting potential, typically around -70 millivolts (mV) for neurons. Inside the cell, there is a higher concentration of potassium ions (K+) and a lower concentration of sodium ions (Na+). Voltage-gated sodium channels are closed, and...
5.4K
Electrical Synapses01:28

Electrical Synapses

8.3K
Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
8.3K
The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

3.2K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.2K
Overview of Synapses01:25

Overview of Synapses

2.2K
A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the synapse and bind to...
2.2K

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相关实验视频

Updated: Jun 20, 2025

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
08:08

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond

Published on: June 24, 2015

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脉冲形状和电压依赖同步在尖端神经网络中的神经网络.

Bastian Pietras1

  • 1Department of Information and Communication Technologies, Universitat Pompeu Fabra, 08018, Barcelona, Spain bastian.pietras@upf.edu.

Neural computation
|July 19, 2024
PubMed
概括

尖端神经网络中的有限脉冲宽度对于集体行为至关重要. 扭曲的脉冲形状,不仅仅是狭窄的脉冲形状,通过电压合有效地同步神经元,为突触传输提供了一个新的补充机制.

科学领域:

  • 计算神经科学是一种神经科学.
  • 神经动力学 神经动力学
  • 复杂的系统复杂的系统.

背景情况:

  • 尖端神经网络 (SNN) 模拟神经自我组织和集体行为.
  • 当前的模型经常使用理想化的,无限狭窄的尖峰,忽视了生物现实主义.
  • 有限脉冲宽度和形状对SNN动态的影响仍然在很大程度上未被探索和辩论.

研究的目的:

  • 在二次整合和火 (QIF) 和甲神经元网络中全面研究脉冲合.
  • 探索有限脉冲宽度和形状在新兴网络动态中的作用.
  • 为了阐明一个电压依赖的尖峰同步机制.

主要方法:

  • 对于全球合的尖端神经元网络,使用了精确的低维描述.
  • 使用任意有限宽度和形状 (对称/不对称) 的平滑脉冲函数建模的相互作用.
  • 在QIF神经元中实施有限宽度脉冲以激活电压依赖的突触导电量.

主要成果:

  • 即时的相互作用通过平均电压合导致集体振荡.
  • 对称的有限宽度脉冲显示有限的同步效率.
  • 不对称的脉冲,偏向于高峰后阶段,很容易诱导集体振荡.
  • 展示了由有限的脉冲宽度促进的电压依赖同步机制.

更多相关视频

Contribution of the Na+/K+ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses
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Contribution of the Na+/K+ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses

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Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
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Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

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相关实验视频

Last Updated: Jun 20, 2025

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
08:08

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond

Published on: June 24, 2015

11.5K
Contribution of the Na+/K+ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses
08:34

Contribution of the Na+/K+ Pump to Rhythmic Bursting, Explored with Modeling and Dynamic Clamp Analyses

Published on: May 9, 2021

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Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
07:33

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

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结论:

  • 有限脉冲宽度对于生物可信的神经网络动态至关重要.
  • 脉冲形状显著影响同步和新兴的集体行为.
  • 这项研究揭示了一种新的同步机制,与传统的突触传输相补充.