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相关概念视频

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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The Thyroid Gland01:23

The Thyroid Gland

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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The Parathyroid Glands00:59

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
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Functions of Thyroid Hormones01:18

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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相关实验视频

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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
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甲状腺癌中的瘤沉积物

Merih Guray Durak1, Deniz Gokcay1, Serra Begum Emecen1

  • 1Department of Pathology, Dokuz Eylul University School of Medicine, Izmir, Turkey.

Medicine
|July 19, 2024
PubMed
概括

瘤沉积物 (TD) 是最近在甲状腺癌中发现的,在甲状腺髓癌和女性中更频繁地出现. 它们的存在表明瘤行为更具侵略性,整体生存率较差,突出显示了它们的预后意义.

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科学领域:

  • 在瘤学瘤学.
  • 病理学 病理学 病理学
  • 癌症研究 癌症研究

背景情况:

  • 瘤沉积 (TDs) 是淋巴疏通通路中的不连续的瘤质量.
  • TDs在各种癌症中显示出不良的预后影响.
  • 甲状腺癌中TDs的发生率和预后值仍未得到充分研究.

研究的目的:

  • 为了调查甲状腺癌中瘤沉积 (TD) 的发生率.
  • 为了确定甲状腺癌病例中TDs的预后值.
  • 分析TD与临床病理特征和生存结果的关联.

主要方法:

  • 对194例甲状腺癌病例进行了回顾性队列研究,并采样/切割了宫淋巴结.
  • 对存在瘤沉积物 (TDs) 的病例进行重新评估.
  • 统计分析以比较发病率并将TD与临床病理因素和存活率相关联.

主要成果:

  • 在54名 (27.8%) 甲状腺癌患者中检测到瘤沉积物 (TD).
  • 甲状腺髓性癌 (TMC) 的TD显著比乳腺状甲状腺癌 (TPC) 的TD更常见 (55.6%对25.0%).
  • TDs与较大的瘤大小,淋巴侵袭,甲状腺外延伸,远程转移和减少整体存活率 (OS) 相关.

结论:

  • 在甲状腺癌中存在瘤沉积物 (TDs),在瘤中更为普遍.
  • TDs的存在与更具侵略性的瘤行为和更差的预后有关.
  • TDs代表甲状腺癌的显著预后标志物,特别影响OS.