2型糖尿病患者服用利拉格卢提德的视网膜病变风险因素
Moeber M Mahzari1,2,3, Abdulmalik M Alanazy1,2, Zeeshan Feroz2,4
1College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Medicine
|July 19, 2024
概括
在2型糖尿病患者中,利拉古胺显著降低了HbA1c和体重. 大多数患者在随访期间糖尿病视网膜病变状态没有变化.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 眼科医生 眼科 眼科
背景情况:
- 利拉格卢提德是一种GLP-1受体激动剂,有效用于2型糖尿病 (T2D) 管理,改善血糖控制,减轻体重,改善心血管结果.
- 关于利拉格卢提德对中东地区糖尿病视网膜病变 (DR) 的影响的数据有限.
- 这项研究调查了沙特阿拉伯用利拉格卢提德治疗的T2D患者的DR特征和风险因素.
研究的目的:
- 为了研究2型糖尿病患者糖尿病视网膜病变的特征和危险因素,在沙特阿拉伯用利拉格卢提德治疗.
- 评估在利拉格卢提德治疗后糖尿病视网膜病变状态的变化.
- 确定与糖尿病视网膜病变的发展或进展相关的因素.
主要方法:
- 从2015年到2021年,对181名2型糖尿病患者 (≥14年) 进行了回顾性队列研究,这些患者接受了利拉格卢提德治疗.
- 数据包括基线和随访视网膜病变评估,HbA1c,BMI,糖尿病持续时间和药物使用.
- 用多变量二元混合效应分析来确定视网膜病变的危险因素.
主要成果:
- 利拉格卢提德治疗导致HbA1c (P < .001) 和体重 (P < .001) 在2年的中位随访后显著降低.
- 在没有基线视网膜病变的患者中,81.6%的患者没有保持视网膜病变.
- 在患有基线视网膜病变的患者中,25.5%的情况有所改善,44.7%的情况没有变化.
- 胰岛素使用 (OR:2.68),年龄较大 (OR:1.03),HbA1c较高 (OR:1.17),高血压 (OR:2.56) 和糖尿病持续时间较长 (OR:1.04) 与视网膜病变有关.
结论:
- 利拉格卢提德有效降低了2型糖尿病患者的HbA1c和体重.
- 大多数接受liraglutide治疗的患者在糖尿病视网膜病变状态中没有显著变化.
- 胰岛素使用,年龄较大,HbA1c较高,高血压和糖尿病持续时间较长是该队列中视网膜病变的重要危险因素.
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