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在PSP和不稳定的PD患者中体质损伤:多模式MRI研究

Maria Eugenia Caligiuri¹, Andrea Quattrone², Maria Giovanna Bianco¹

¹Neuroscience Research Center, Department of Medical and Surgical Sciences, University "Magna Graecia", Catanzaro, Italy.

NeuroImage. Clinical

|July 19, 2024

概括

脑部成像显示,骨损伤,特别是在骨区域,与帕金森病的姿势不稳定性 (PI) 有关.

科学领域:

神经成像是一种神经成像.
神经学神经学
神经科学是一个神经科学.

背景情况:

姿势不稳定 (PI) 是帕金森病 (PD) 和渐进性上核性麻 (PSP) 中显著的致残症状.
导致PI的潜在大脑变化仍然不完全理解.
骨损伤被研究为PI发展的潜在因素.

研究的目的:

调查帕金森病 (PD) 和渐进性上核性麻 (PSP) 患者的姿势不稳定性和骨损伤之间的关联.
使用多式磁共振成像 (MRI) 来评估大脑变化.

主要方法:

112名PD患者 (按PI存在分层),69名PSP患者和38名健康对照人接受了3T大脑MRI.
结构和扩散MRI评估了体 (CC) 厚度,分数异构性 (FA) 和平均扩散性 (MD).
线性回归分析了成像指标和PI得分之间的关联.

主要成果:

与对照人群相比,PSP和PD患者都有PI,显示身体体 (CC) 参与;PD患者没有PI与对照人群没有差异.
在PSP患者中,CC损伤比PD患者更严重和更广泛.
在患有PI的PD患者中,CC基因表现出显著的微观结构变化 (MD和FA),该地区的MD是PI的主要贡献者.

结论:

在不稳定的PD和PSP患者中,腔微观结构的改变与PI有关.
这些发现为PI的病理生理学提供了新的见解.
鉴定到的状细胞变化可以作为成像生物标志物来评估PI进展和治疗反应.

关键词:

体 (corpus callosum) 是一个体.扩散张力成像的成像方法帕金森病是帕金森氏症的一种疾病.姿势不稳定性姿势不稳定性渐进性的超核性.

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