生物分子液体-液体相分离的调节通过偏好的水合和小奥斯莫利特与蛋白质的相互作用

Keiji Kitamura1, Ayano Oshima2, Fuka Sasaki1

  • 1Graduate School of Pharmacy, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan.

概括

三甲基胺N-氧化物 (TMAO) 稳定生物分子液体液相分离 (LLPS),而尿素则使其不稳定. 这些氧化物调节FUS蛋白LLPS通过偏好的水合和直接相互作用,即使在极端条件下.

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