在患有 osteogenesis imperfecta 的儿科患者中听力损失的表征
Chelsea Cleveland1, Jamil Hayden1, Tekin Baglam1
1Department of Otolaryngology-Head and Neck Surgery, University Hospitals Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
International journal of pediatric otorhinolaryngology
|July 19, 2024
概括
患有 osteogenesis imperfecta (OI) 的儿童有明显更高的听力损失风险. 这项研究发现,患有OI的儿科患者患有任何形式的听力损失的可能性几乎是五倍,导电性听力损失是最常见的.
科学领域:
- 遗传学和遗传性疾病
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 儿科健康 儿科健康
背景情况:
- 骨质发生不完善 (Osteogenesis Imperfecta,简称OI) 是一种影响1型原蛋白的普遍遗传性疾病.
- 听力损失是OI的一个显著并发症,影响了46-58%的患者,之前的研究主要集中在成人身上.
- OI可能导致导电性,神经传感或混合性听力损失.
研究的目的:
- 为了研究骨质发育不完善 (OI) 和儿科患者的听力损失之间的关系.
- 量化不同类型的OI诊断儿童听力损失的患病率和风险.
主要方法:
- 使用了TriNetx分析网络,这是一个大规模的非识别电子健康记录数据库.
- 18岁或更年轻的OI诊断患者的查询数据.
- 排除了先天性细胞大脑病毒,内耳形或噪音引起的听力损失的病例.
主要成果:
- 10.07%的儿科OI患者 (n=3256) 患有某种形式的听力损失.
- 导电性听力损失的患病率为5.71%,神经传感性听力损失为3.01%,混合性听力损失为1.35%.
- 相对风险显示OI患者与对照人群相比,所有听力损失类型的风险显著增加,混合听力损失风险最高 (13.86).
结论:
- 这项研究代表了迄今为止关于OI和儿科听力损失的最大分析.
- 患有OI的儿童患者患有任何听力损失的可能性增加了近五倍.
- 导电性听力损失是OI儿童中最常见的类型,而混合性听力损失具有最高的相对风险.
更多相关视频
06:04Systematic Hearing Performance Evaluation Process for Adolescents with Cochlear Implantation at Early Ages
Published on: March 24, 2023
373
09:07Author Spotlight: Advancing Endoscopic Ossiculoplasty – Techniques, Innovations, and Practical Guidance for Clinical Integration
Published on: January 26, 2024
2.3K
相关概念视频
01:11The Auditory Ossicles
1.6K
The auditory ossicles of the middle ear transmit sounds from the air as vibrations to the fluid-filled cochlea. The auditory ossicles consist of two malleus (hammer) bones, two incus (anvil) bones, and two stapes (stirrups), one on each side. These bones develop during the fetal stage and are the ones to ossify first. They are fully mature at birth and do not grow afterward.
The aptly named stapes look very much like a stirrup. The three ossicles are unique to mammals, and each plays a role in...
The aptly named stapes look very much like a stirrup. The three ossicles are unique to mammals, and each plays a role in...
1.6K
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K