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Updated: Jun 20, 2025

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry
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SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

Published on: January 6, 2017

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降低CBLs的调节预示着T细胞泛化导致自身免疫

Aurobind Vidyarthi1, Joe Craft1

  • 1Yale University School of Medicine, New Haven, CT 06520-8031, USA.

Cell chemical biology
|July 19, 2024
PubMed
概括

研究人员发现,在狼患者的T毛囊辅助细胞 (Tfh) 中,E3泛素连接酶CBL和CBL-B的下调. 这会影响Tfh细胞转录因子BCL6,导致自身免疫.

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