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Updated: Jun 20, 2025

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
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Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

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在POU2F-POU2AF转录因子驱动的恶性瘤中准mSWI/SNF复合体

Tongchen He1, Lanbo Xiao2, Yuanyuan Qiao3

  • 1Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Urology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

Cancer cell
|July 19, 2024
PubMed
概括

小细胞肺癌 (SCLC-P) 和多发性髓瘤易受mSWI/SNF ATPase降解剂的影响. 这种向治疗破坏了关键的转录因子,抑制了瘤的生长,没有毒性.

关键词:
在 IRF4 基础上,IRF4 是一个 IRF4 项目.在POU2AF1/2/3中使用.在POU2F3F3中.这就是PROTAC.在SCLC中,SCLC是最重要的.在SMARCA2/4/4中使用.mSWI/SNF复合体是一个复合体.多发性骨髓瘤是多发性骨髓瘤的一种.蛋白质溶解的目标是木乃伊.小细胞肺癌是一种小细胞肺癌.

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