相关实验视频
Updated: Jun 20, 2025

05:47
Isolation of Murine Lymph Node Stromal Cells
Published on: August 19, 2014
31.3K
淋巴局部化的Treg-mregDC交叉限制了抗原贩运,并抑制了抗瘤免疫力
Siyuan You1, Shuqin Li1, Lingsu Zeng2
1State Key Laboratory of Cellular Stress Biology, Xiang'an Hospital, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University; Xiamen, Fujian 361102, China.
Cancer cell
|July 19, 2024
概括
调节性T细胞 (Tregs) 和成熟的树突细胞 (mregDCs) 在瘤微环境中形成了一个利基,抑制抗瘤免疫力. 破坏这种Treg-mregDC相互作用会抑制瘤生长,提供新的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
- 瘤微环境研究 研究
背景情况:
- 瘤微环境 (TME) 极大地影响瘤进展和免疫治疗结果.
- 了解TME内部的特定细胞相互作用和空间安排是必不可少的,但具有挑战性.
- 众所周知,调节性T细胞 (Tregs) 抑制了抗瘤免疫反应.
研究的目的:
- 阐明TME内部影响瘤生长和免疫治疗的精确细胞相互作用和空间组织.
- 确定调节性T细胞 (Tregs) 影响抗瘤免疫反应的机制.
- 探索TME中的潜在治疗点,以增强抗癌免疫力.
主要方法:
- 使用先进的多重成像技术,可视化TME中的细胞相互作用.
- 特定细胞种群的特征,包括调节性T细胞 (Tregs) 和成熟树突细胞 (mregDCs).
- 分析Treg积累模式及其与淋巴血管和树突细胞的关联.
主要成果:
- 发现调节性T细胞 (Tregs) 在周围瘤层的淋巴血管周围积聚.
- 富含免疫调节分子 (mregDCs) 的成熟树突细胞被确定为Treg积累的关键促进者,形成一个周周淋巴Treg-mregDC.
- 在这个利基范围内,mregDCs促进Treg激活,这随后阻碍了瘤抗原运输到淋巴结,从而抑制了抗瘤适应性免疫力.
- 抑制对mregDCs的Treg招募导致了瘤进展的减少.
结论:
- 在TME内的新型周淋巴Treg-mregDC利基抑制了抗瘤自适应性免疫反应.
- 这种利基通过抑制瘤抗原贩运和T细胞激活来阻碍抗瘤免疫力.
- 准Treg-mregDC相互作用为增强抗瘤免疫疗法和抑制瘤生长提供了一个有希望的策略.
相关概念视频
T Cell Types and Functions
990
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
990
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Cell-mediated Immune Responses
68.0K
Overview
68.0K
T Cell Activation and Clonal Selection
696
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
696
Tumor Immunotherapy
504
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
504

