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Updated: Jun 20, 2025

Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
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Published on: July 17, 2020

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一个化学平台,以轻度循环反应有效选基于arylazopyrazole的可光切换CENP-E抑制剂

Kazuya Matsuo1, Honoka Ogawa1, Shusuke Yamaoka1

  • 1Faculty of Molecular Chemistry and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.

Bioorganic & medicinal chemistry letters
|July 19, 2024
PubMed
概括

研究人员发现了新型的阿里拉佐皮拉尔抑制剂,用于线粒运动蛋白CENP-E. 这项工作澄清了体外和细胞内可光切换抑制剂的结构-活性关系.

关键词:
亚里拉佐皮拉佐 (arylazopyrazole) 是一种一种在CENP-E中.摄影药理学 摄影药理学照片交换机的照片交换机

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The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
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The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
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