在前列腺癌和乳腺癌中,肌层-上皮层相互作用的微RNA特征

相关实验视频

Updated: Jun 20, 2025

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Ankit Roy Choudhury¹, A Muni Nagesh², Surabhi Gupta²

¹Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, India; Department of Biology, Philipps University, Marburg, Germany.

Experimental cell research

|July 19, 2024

概括

荷尔蒙调节的microRNAs (miRNAs) 破坏前列腺和乳腺组织的正常细胞相互作用,导致癌症的发展. 了解这种相互作用是未来癌症研究的关键.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
细胞生物学细胞生物学

背景情况:

肌体-上皮相互作用对于前列腺和乳腺组织的发育和疾病至关重要.
非编码RNAs,特别是microRNAs (miRNAs),越来越多地被认为是它们在细胞过程中的复杂作用.
类固醇激素如雄激素和雌激素显著影响前列腺和乳腺组织,分别.

研究的目的:

审查激素调节的miRNAs在癌症发生过程中中破坏树皮-上皮沟通中的作用.
要突出激素,miRNA和前列腺癌和乳腺癌中的细胞相互作用之间的相互作用.
为未来研究组织微环境中miRNA介导的变化提供基础.

主要方法:

文献综述专注于研究研究激素,miRNAs和前列腺癌和乳腺癌中的树皮-上皮相互作用.
对激素影响miRNA表达机制的现有研究进行分析.
综合了关于这些激素-miRNA相互作用如何影响细胞通信和癌症进展的发现.

主要成果:

受到激素影响的miRNAs显著改变了前列腺和乳腺组织中正常的树皮-上皮交叉.
特定的miRNA被确定为癌症发生过程中细胞相互作用的激素调节中的关键调解者.
激素,miRNA和细胞通信之间的相互作用是癌症发展的关键因素.

结论:

荷尔蒙调节的miRNAs在扰乱树皮-上皮相互作用中起着关键作用,驱动前列腺和乳腺癌发生.
需要进一步研究miRNA介导的树皮-上皮相互作用变化的荷尔蒙控制.
针对这些激素-miRNA通路可能为前列腺癌和乳腺癌提供新的治疗策略.

关键词:

这就是为什么AR AR AR AR.类激素是一种安德روج因.乳房乳房乳房与癌症相关的纤维细胞.在这里,你会看到一个很棒的景点.雌激素是一种雌激素.外基因组是外基因组的组成部分.前列腺前列腺前列腺肌层-上皮层相互作用这是一个小RNARNA.

更多相关视频

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR

Published on: May 16, 2012

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Published on: November 26, 2015

相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...