代谢功能障碍相关的脂肪肝疾病到晚期肝病的进展中的饮食模式:一项前性队列研究
Tengfei Li1, Jianhui Zhao2, Haoze Cao3
1Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Department of Big Data in Health Science School of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou, Zhejiang, China; Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province, Hangzhou, Zhejiang, China; National Innovation Center for Fundamental Research on Cancer Medicine, Hangzhou, Zhejiang, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China; ZJU-Pujian Research & Development Center of Medical Artificial Intelligence for Hepatobiliary and Pancreatic Disease, Hangzhou, Zhejiang, China.
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 显著增加肝脏疾病的风险. 采用特定的饮食模式,如替代地中海饮食,可以降低这种风险,强调饮食.
科学领域:
- 肝病学和胃肠道学
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一种普遍且严重的健康问题.
- 饮食干预对于管理MAFLD和预防其进展至关重要.
研究的目的:
- 为被诊断患有MAFLD的个人制定饮食模式建议.
- 为了研究各种饮食模式与肝病风险之间的联系,在一个大队伍中.
主要方法:
- 利用英国生物银行队列来识别患有MAFLD的个体.
- 从饮食记录中得出九个饮食模式得分.
- 使用多变量考克斯回归和对比测试来分析关联和异质性.
主要成果:
- MAFLD与慢性肝病 (CLD),严重肝病 (SLD),肝癌和与肝脏相关的死亡风险增加密切相关.
- 坚持诸如替代地中海饮食 (aMED),行星健康饮食 (PHD),植物性低碳水化合物饮食 (pLCD) 和健康的植物性饮食指数 (hPDI) 这样的饮食与降低了CLD和SLD风险有关.
- 一种不健康的植物性饮食指数 (uPDI) 与较高的CLD,SLD和肝脏相关死亡风险相关.
结论:
- MAFLD对随后的肝脏疾病的发展做出了重大贡献.
- 饮食模式在治疗和预防MAFLD患者肝病并发症方面发挥着至关重要的作用.
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