母亲早期怀孕抑郁症和纵向胎儿生长之间的关联
Jiaying Wu1, Fangyue Zhou1, Yishu Wang1
1The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, China; Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China.
Journal of affective disorders
|July 19, 2024
概括
怀孕早期的孕产妇抑郁与更大的胎儿生长,更高的出生体重,以及对子女妊娠年龄的宏观和大尺寸的风险增加有关. 这凸显了监测产前抑郁症的母亲胎儿发育的重要性.
科学领域:
- 产科和妇科 产科和妇科
- 围产期心理健康问题
- 胎儿发育研究 胎儿发育研究
背景情况:
- 在怀孕中期到晚期对胎儿生长的孕产妇抑郁的影响得到了充分的研究.
- 怀孕早期母亲抑郁症和胎儿子宫内生长之间的关联仍然不太清楚.
研究的目的:
- 研究怀孕早期母亲抑郁症状与胎儿生长轨迹之间的关系.
- 确定早期产前抑郁症对胎儿生物识别和出生结果的影响.
主要方法:
- 一项前性研究涉及上海23465名孕妇及其后代.
- 在怀孕14周之前使用患者健康问卷 (PHQ-9) 评估产前抑郁症.
- 多级模型与分数多项式用于比较胎儿成长轨迹跨不同的母亲抑郁状态在三个季度.
主要成果:
- 怀孕早期出现抑郁症状的母亲表现出较高的纵向胎儿生长轨迹,包括胎儿体重增加 (β=0.33).
- 在怀孕23周之前,在患有抑郁症状的妇女中,观察到胎儿腹周的增加.
- 患有早期抑郁症的母亲生下来的后代出生时体重显著增加 (+14.13克),并增加了怀孕年龄 (aOR=1.64) 和宏观体 (aOR=1.21) 严重的大小的风险.
结论:
- 怀孕早期母亲抑郁症与胎儿生物识别和出生体重的增加有关.
- 怀孕年龄和宏观体的严重大小的更高风险在患有早期怀孕抑郁症的母亲的后代中观察到.
- 局限性包括使用自我评价尺度来评估抑郁症,以及缺乏对长期后代影响的探索.
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