低度泌尿腺癌以自然加速的速度复发,随着时间的推移自然加速
Alex Sankin1, Priya Dave1, Louise-Rae Cherrill2
1Department of Urology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY.
Urology
|July 19, 2024
概括
超过一半的低度中期风险非肌肉侵入性膀癌 (LG IR-NMIBC) 患者将出现复发. 一些患者表现出加速复发的模式,可能会为未来的监测和治疗策略提供信息.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 癌症研究 癌症研究
背景情况:
- 非肌肉侵入性膀癌 (NMIBC) 是一种慢性疾病,需要终身监测.
- 低级中等风险 (LG IR-NMIBC) 占NMIBC案件的很大一部分.
- 了解复发模式对于优化患者管理和降低医疗保健成本至关重要.
研究的目的:
- 为了研究LG IR-NMIBC患者的复发节奏.
- 确定影响复发率的临床决定因素.
- 为改善NMIBC的监测策略提供信息.
主要方法:
- 从西米德兰斯的膀癌预后计划 (BCPP) 分析基线和后续数据.
- 评估整体复发率和无复发间隔的评估.
- 用于计算无复发间隔的Kaplan-Meier方法.
主要成果:
- 分析了379名LG IR-NMIBC患者 (G1/G2 pTa);中位数年龄为70岁,75%是男性.
- 随访时间中位数为4.2年,53%的患者在5年内复发.
- 一年后无复发生存率为75%,四年后为50%.
结论:
- 超过一半的LG IR-NMIBC患者经历了疾病复发.
- 在一小部分患者中观察到加速复发模式.
- 复发加速可以作为个性化监测和治疗的生物标志物.
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