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在炎症性肠道疾病中,内镜粘膜切除用于横向扩散的病变的比较结果
Varun T Angajala1, James L Buxbaum1, Jennifer Phan1
1Department of Internal Medicine, Division of Gastrointestinal and Liver Diseases, University of Southern California, Keck School of Medicine, Los Angeles, United States.
与对照组相比,在患有炎性肠病 (IBD) 的患者中,用于横向扩散病变 (LSL) 的内镜粘膜切除 (EMR) 显示出更高的复发率. 建议在IBD患者中对EMR进行专家中心和密切监测.
科学领域:
- 胃肠病学 胃肠病学
- 内镜检查是指内镜检查.
- 在瘤学瘤学.
背景情况:
- 在一般人群中,内镜粘膜切除 (EMR) 对横向扩散的病变 (LSL) 有效,但其在炎症性肠病 (IBD) 中的使用受到争议.
- 对IBD相关的LSL的EMR结果需要进一步描述.
研究的目的:
- 为了比较IBD患者与无IBD患者的LSLEMR结果.
- 确定与IBD患者LSLs在EMR后复发相关的因素.
主要方法:
- 追溯观察队列研究,将接受LSLEMR的IBD患者与对照组进行比较.
- 主要结局:组织学复发. 二次结果:整体切除率和不良事件.
- 多变量混合效应逻辑回归用于识别与复发相关的因素.
主要成果:
- 总共分析了155名患者的210个病变;91%是腺瘤或状状病变.
- 与对照组 (20.9%) 相比,IBD组 (30.4%) 的组织学复发率更高.
- 在IBD组 (8.7%) 和对照组 (56.7%) 中,分体切除率明显较低.
结论:
- 与非IBD患者相比,IBD患者的LSL的EMR与复发的风险更高.
- 在IBD患者中,EMR增加了复杂性,需要在专家中心执行,并加强了内镜监测协议.
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