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Updated: Jun 20, 2025

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
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Published on: October 15, 2017

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一个I期研究,以确定Capivasertib在健康男性参与者的绝对生物可用性和吸收,分布,新陈代谢和分泌

Claire Miller1, Martin Wild1, Zhoupeng Zhang1

  • 1Clinical Pharmacology and Quantitative Pharmacology, BioPharmaceuticals R&D (C.M.), Drug Metabolism and Pharmacokinetics, Oncology R&D (M.W.), Global Medicines Development, Oncology R&D (R.S., D.S.), Integrated Bioanalysis, BioPharmaceuticals R&D (C.B.), and Pharmaceutical Sciences, R&D (R.A.B., M.G.), AstraZeneca, Cambridge, United Kingdom; Drug Metabolism and Pharmacokinetics, Oncology R&D (Z.Z.) and Clinical Pharmacology and Quantitative Pharmacology, BioPharmaceuticals R&D (J.D.), AstraZeneca, Waltham, Massachusetts; Quotient Sciences Ltd, Ruddington, Nottingham, United Kingdom (S.S.); and Clinical Pharmacology and Quantitative Pharmacology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden (M.C.).

Drug metabolism and disposition: the biological fate of chemicals
|July 19, 2024
PubMed
概括

这项研究确定了强有力的AKT抑制剂capivasertib的药理动力学. 绝对生物利用率为28.6%,排泄物中95.1%的剂量恢复,为其临床发展提供了信息.

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