在自闭症谱系障碍中CBD的治疗潜力
João F C Pedrazzi1, Lucas Hassib2, Frederico R Ferreira3
1Department of Neurosciences and Behavioral Sciences, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
International review of neurobiology
|July 19, 2024
概括
大麻素 (CBD) 通过与内分泌系统相互作用,显示出治疗自闭症谱系障碍 (ASD) 症状的前景. 这种非心理模拟性化合物也可能对肠道微生物群产生积极影响,为ASD提供安全,多目标的治疗候选者.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种神经发育状况,药物治疗有限.
- 大麻素 (CBD) 是一种大麻sativa化合物,在神经和精神疾病中已经显示出治疗潜力.
- 内分离系统对生理过程,社会行为和神经元发育至关重要,所有这些都与ASD相关.
研究的目的:
- 探索大麻素 (CBD) 对自闭症谱系障碍 (ASD) 的治疗潜力.
- 在ASD的背景下,研究CBD与内分泌系统的相互作用.
- 为了检查CBD对ASD症状,并发症和肠-大脑轴的影响.
主要方法:
- 审查初步的临床试验结果关于CBD在人类与ASD.
- 分析CBD的药理特征和与内分泌系统的相互作用.
- 探索CBD对肠道微生物群的影响和对ASD的影响的新兴证据.
主要成果:
- 初步的临床数据表明,CBD可能会调节特定的ASD症状和并发症.
- CBD与内分泌系统的相互作用与ASD病理生理学有关.
- 新出现的证据将CBD与肠道微生物群的调节联系在一起,影响肠-大脑轴.
结论:
- 大麻 (CBD) 是治疗ASD中心症状和相关并发症的潜在候选药物.
- CBD的多目标药理学特征和安全性特征支持将其考虑用于ASD治疗.
- 进一步研究CBD对ASD肠-大脑轴的影响是有必要的.
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