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大麻二醇和疼痛

Glauce Crivelaro Nascimento1, Daniela Escobar-Espinal1, Gabriela Gonçalves Bálico1

  • 1Department of Basic and Oral Biology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.

International review of neurobiology
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概括

大麻醇 (CBD) 显示出慢性疼痛缓解的希望,为不充分的传统治疗提供了更安全的替代方案. 需要进一步的研究来了解它的全部潜力和管理各种类型的疼痛的机制.

关键词:
大麻二醇 (Cannabidiol) 是一种化疗诱导的外围神经病变肌肉骨系统的疼痛神经病变性疼痛是一种神经性疼痛.

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科学领域:

  • 药理学 药理学是指药理学的学科.
  • 疼痛管理 疼痛管理
  • 神经科学是一个神经科学.

背景情况:

  • 慢性疼痛影响全球30%以上的成年人,导致严重的残疾.
  • 目前的药物疗法为不到70%的患者提供缓解,突出显示需要替代方案.
  • Cannabidiol (CBD) 是一种大麻素,目前正在研究其潜在的止痛特性和安全性.

研究的目的:

  • 探索大麻 (CBD) 在治疗慢性疼痛方面的治疗潜力.
  • 审查关于CBD作为另一种疼痛管理策略的有效性和安全性的现有证据.
  • 了解CBD可能施加止痛作用的机制.

主要方法:

  • 关于CBD镇痛作用的临床前 (动物) 研究的综述.
  • 分析现有的关于在疼痛管理中使用大麻素的文献.
  • 检查CBD与内分泌,炎症和感觉系统的相互作用.

主要成果:

  • 动物研究表明,CBD具有缓解疼痛的特性.
  • 与传统止痛药相比,CBD可能提供了一个更安全的替代方案,降低了成风险.
  • 有证据表明,对与癌症有关的神经病,关节炎和肌肉骨疼痛有潜在的益处.

结论:

  • 大麻 (CBD) 是慢性疼痛管理的一个有希望的途径,特别是在传统治疗不足的情况下.
  • 虽然有希望,但CBD治疗疼痛的有效性和最佳使用需要进一步严格调查.
  • 了解CBD在调节关键生理系统中的作用,对于其在缓解疼痛方面的临床应用至关重要.