设计的pH响应分子印记聚合物作为一个载体,以控制和可持续的capecitabine释放
Zimeng Guo1, Haijiao Zheng2, Jiutong Ma2
1School of Pharmaceutical Sciences, Jilin University, Changchun, 130021, China.
Analytica chimica acta
|July 19, 2024
概括
开发了一种新型的pH响应分子印记聚合物 (MIP) 载体,用于控制的capecitabine (CAPE) 药物输送. 这种纳米载体显示出有效治疗瘤的潜力,具有良好的生物相容性.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 聚合物化学 聚合物化学
背景情况:
- 开发有效的药物输送系统 (DDS) 对向癌症治疗至关重要.
- 开普西他 (CAPE) 是一种广泛使用的化疗剂,其常规输送方式有限.
- 响应pH的纳米载体在瘤微环境中具有可控药物释放的优势.
研究的目的:
- 设计和合成一个响应pH的分子印记聚合物 (MIP) 载体,用于控制和可持续的capecitabine (CAPE) 释放.
- 调查开发的DDS的药物载荷,释放动力学和生物相容性.
- 探索MIP载体在瘤治疗应用中的潜力.
主要方法:
- 用4-甲基酸对SiO2基质进行功能化,以赋予pH响应性.
- 纳入光素异硫酸酸盐用于细胞内局部化可视化.
- 在MIP载体上吸附capecitabine (CAPE).
- 在弱酸性环境中的体外释放研究.
- 密度函数理论 (DFT) 计算用于机制调查.
- 在体外生物相容性和细胞毒性测定.
主要成果:
- 在MIP载体上实现了CAPE的高封装效率.
- 证明了CAPE的受控和可持续的释放,由薄酸性环境中酸键的断裂引发.
- 密度函数理论计算阐明了吸附和释放机制.
- 在体外实验证实了DDS的良好的生物相容性和显著的抑制效率.
- 通过使用光素异硫酸,成功可视化了细胞内定位.
结论:
- 开发的pH响应的MIP载体是可用于控制的capecitabine输送的合格平台.
- DDS表现出优异的生物相容性和瘤治疗的治疗潜力.
- 这种纳米载体设计对先进的癌症治疗应用有前途.
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