太空飞行增加了sarcoplasmic网膜Ca2+泄漏,这不能通过BuOE治疗来抵消
Jessica L Braun1,2, Val A Fajardo3,4
1Department of Kinesiology, Brock University, St. Catharines, ON, Canada.
NPJ microgravity
|July 19, 2024
概括
太空飞行会导致小鼠的肌肉缩和处理受损,但抗氧化剂 (Manganese) (III) (Meso-tetrakis) (N-n-butoxyethylpyridinium-2-yl) (BuOE) 没有阻止这些影响. 为了有效的对策,需要进一步的研究.
科学领域:
- 太空生物学空间生物学
- 骨肌肉生理学 骨肌肉生理学
- 生物化学 生物化学
背景情况:
- 微重力通过肌肉卸载诱导骨肌肉缩和衰弱,部分原因是 (Ca2+) 失调.
- 在太空飞行肌肉中,sarco(endo) 质网膜Ca2+ ATPase (SERCA) 的Ca2+吸收受损与活性氧/物种 (RONS) 有关.
研究的目的:
- 调查抗氧化剂 (MnTnBuOE-2-PyP5+或BuOE) 是否可以减轻太空飞行引起的肌底肌肉缩和SERCA功能障碍.
主要方法:
- 分析了35天在国际空间站进行太空飞行的雄性小鼠的 Soleus 肌肉.
- 小鼠接受了盐水或BuOE的治疗.
- 测量结果包括soleus:体质比,SERCA离子孔比 (SR Ca2+泄漏),以及4-hydroxynonenal (4-HNE) 含量 (RONS标志物).
主要成果:
- 太空飞行显著降低了soleus:身体质量比.
- 太空飞行显著增加了SERCA的离子体比率和4-HNE含量.
- 治疗BuOE并没有挽救观察到的肌肉缩,增加的Ca2+泄漏或升高的RONS标志物.
结论:
- 太空飞行会导致显著的单体肌肉缩和sarcoplasmic网膜 (SR) Ca2+泄漏.
- 抗氧化剂BuOE在抵消这些太空飞行引起的变化方面无效.
- 未来的研究应该探索针对SERCA激活或减少Ca2+泄漏的治疗方法.
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