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Updated: Jun 20, 2025

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

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在真核生物中,Pif1螺旋酶通过保留形来解开G-四重复和dsDNA

Zebin Hong1, Alicia K Byrd2, Jun Gao3

  • 1Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Proteos, Singapore, Republic of Singapore.

Nature communications
|July 19, 2024
PubMed
概括

在Saccharomyces cerevisiae Pif1中,螺旋酶在它的1A域中使用明显的形区域展开G-四重复的DNA结构. 这种机制对于解决DNA双重复合和G四重复合,保持基因组稳定性至关重要.

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