对心血管病理生理学的计算建模,以分层化商业太空飞行风险
Paul D Morris1,2, Ryan A Anderton3, Karina Marshall-Goebel4
1Division of Clinical Medicine, University of Sheffield, Sheffield, UK. paul.morris@sheffield.ac.uk.
Nature reviews. Cardiology
|July 19, 2024
概括
商业太空飞行为公众打开了大门,但对那些有健康状况的人来说存在风险. 计算机建模可以预测加速力带来的心血管风险,从而提高所有旅客的太空飞行安全.
科学领域:
- 航空航天医学 航空航天医学
- 心血管生理学心血管生理学
- 计算生物学 计算生物学
背景情况:
- 太空旅行正在扩大,包括公众,许多人有先前存在的健康状况.
- 之前的太空飞行研究集中在高度选的宇航员上,在了解不同人群的风险方面留下了差距.
- 太空飞行中的加速力 (G) 可能会对健康构成风险,特别是对于心血管问题的人来说.
研究的目的:
- 审查用于评估商业航天中心血管风险的计算建模方法.
- 确定预测加速力对具有先前心血管疾病的个体的影响的方法.
- 加强商业轨道下太空飞行参与者的安全协议.
主要方法:
- 探索人类心血管病理生理学的最先进,零维,分隔式模型.
- 模拟加速力,恒温调节,以及通风-透气匹配.
- 利用来自长臂离心机设施 (NASA,ESA) 的数据进行模型验证和风险分层.
主要成果:
- 计算模型可以模拟G力对心血管系统的生理影响.
- 这些模型提供了一种非侵入性方法,用于预测患有病理的个体与太空飞行相关的健康风险.
- 商业航天参与者的风险分层可以通过预测建模来改进.
结论:
- 计算建模是在不断扩大的商业太空飞行行业中评估心血管风险的宝贵工具.
- 预测模型可以帮助确定太空飞行参与者的资格,必要的修改或进一步培训.
- 这种方法提高了空间旅行的安全性和可访问性,使更广泛的人口.
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