产妇,新生儿和营养风险因素对医疗和手术性死性肠球炎的风险因素
Clare Essex1, Clifford Hegedus2, Katherine Vincent2
1Medical University of South Carolina, 96 Jonathan Lucas Street Suite 601, MSC 617, Charleston, SC, 29425, USA.
概括
某些临床指标,如CRP升高和血小板减少,表明手术性结核性肠球炎 (NEC) 的风险增加. 母乳和强化剂与更好的结果有关,在NEC病例中减少了对手术或死亡的需要.
科学领域:
- 新生儿医学 新生儿医学
- 儿科手术 儿科手术
- 临床研究 临床研究
背景情况:
- 结核性肠球炎 (NEC) 是新生儿的严重胃肠道疾病.
- 识别NEC进展的风险因素对于及时干预至关重要.
研究的目的:
- 确定孕产妇和新生儿风险因素,预测诊断出NEC病例的手术进展或死亡率.
主要方法:
- 对216例NEC病例 (2010-2020年) 的回顾性分析评估了47个人口和临床因素.
- 在149例NEC发病时的营养被评估.
- 结果的比较是外科NEC (手术或死亡) 与医疗NEC (用抗生素解决/肠休息).
主要成果:
- 手术NEC的危险因素包括C反应蛋白 (CRP) 升高,血小板数量下降,内托普支持,输管治疗和诊断后24小时内呈阳性血液培养.
- 手术NEC的婴儿在出生时表现出更大的腹周.
- 母乳摄入量和人乳强化剂使用与医学NEC有关,强化母乳显示的进展率最低.
结论:
- 当存在已识别的风险因素时,对外科NEC的临床怀疑增加是合理的.
- 早期识别这些风险因素可以指导NEC的管理策略.
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