环境中毒物如何通过氧化应激影响卵细胞成熟?
Reza Rajabi-Toustani1, Qinan Hu1, Shuangqi Wang1
1Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Advances in anatomy, embryology, and cell biology
|July 19, 2024
概括
环境中有毒物质通过引起氧化应激来破坏哺乳动物卵细胞的成熟,从而导致线粒体功能障碍和异常形形成. 本综述详细介绍了这些因素如何影响变重启和卵细胞发育.
科学领域:
- 生殖生物学 生殖生物学
- 毒理学 毒理学 毒理学
- 细胞生物学 细胞生物学
背景情况:
- 哺乳动物的 oogenesis 开始在出生前,暂停在 I 预相,直到白化激素 (LH) 激增.
- 卵细胞成熟是从第一阶段到第二阶段恢复平移的过程,对于排卵和受精至关重要.
- 环境中有毒物质可以诱导氧化应激,对生殖过程产生负面影响.
研究的目的:
- 审查破坏哺乳动物卵细胞成熟的环境毒素.
- 为了分类导致线粒体功能障碍和异常形形成的有毒物质.
- 讨论阻碍卵细胞成熟的机制,包括线粒体功能,螺纹形成和DNA损伤反应.
主要方法:
- 对影响卵细胞成熟的环境毒素的文献综述.
- 根据诱导的细胞缺陷对有毒物质进行分类.
- 对毒性的分子和细胞机制的讨论.
主要成果:
- 环境中毒物会产生过度的氧化应激,扰乱卵细胞的成熟.
- 关键缺陷包括线粒体功能障碍和异常的线形成.
- 损坏的线粒体功能,螺旋组装和DNA损伤反应阻碍了半球分裂的恢复.
结论:
- 环境中毒物的氧化应激是对卵细胞成熟的重大威胁.
- 了解这些机制对于生殖健康和毒理学至关重要.
- 需要进一步的研究,以减轻环境毒素对女性生育能力的影响.
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