地中海饮食和与肠道微生物群和儿科发病多发性硬化症的关联,使用三变量分析
Ali I Mirza1,2, Feng Zhu1, Natalie Knox3,4
1Department of Medicine (Neurology), The University of British Columbia, Vancouver, BC, Canada.
Communications medicine
|July 19, 2024
概括
富含纤维和铁的地中海饮食可以降低患多发性硬化症 (MS) 的风险. 饮食影响肠道微生物,可能会在儿科MS中调解这种保护作用.
科学领域:
- 神经免疫学 神经免疫学
- 微生物组研究的研究.
- 营养科学 营养科学
背景情况:
- 肠道微生物群在多发性硬化症 (MS) 发病过程中的作用尚不清楚.
- 了解饮食-MS-微生物群轴对于制定预防策略至关重要.
研究的目的:
- 调查饮食模式,肠道微生物群组成和儿科发病多发性硬化症风险之间的关系.
主要方法:
- 一项病例控制研究涉及44例儿科多发性硬化症病例和51例对照.
- 通过食物频率问卷评估的饮食摄入量.
- 从便样本分析的肠道微生物群.
主要成果:
- 较高的地中海饮食得分与MS几率下降37%相关.
- 增加纤维和铁的摄入量也显示出一种保护性关联.
- 饮食模式,而不是MS状态,主要推动了肠道微生物群的变化.
- 特定的肠道微生物与饮食和多发性硬化有关,这表明它们起着调解作用.
结论:
- 在多发性硬化症的背景下,饮食和肠道微生物群的相互作用是重要的.
- 饮食干预措施,特别是那些促进地中海饮食的干预措施,可能为MS预防或管理提供一种新的方法.
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