鱼类废弃物衍生的Hydroxyapatite纳米结构与黑米葡萄酒相结合,具有潜在的抗氧化和抗菌反应
Prakashkumar Nallasamy1, Suganathan Muthalagu Ramalingam Muthalagu1, Suganthy Natarajan2
1Bionanomaterials Research Lab, Department of Nanoscience and Technology, Alagappa University, Karaikudi, Tamil Nadu, India.
Current microbiology
|July 19, 2024
概括
绿色纳米技术提供了一种可持续的解决方案来打击抗生素耐药性. 封装黑米葡萄酒 (BRW) 的Hydroxyapatite (HAP) 纳米颗粒显示出强大的抗微生物和抗菌膜活性,使它们成为预防感染的有希望的药物.
科学领域:
- 绿色纳米技术 绿色纳米技术
- 生物材料科学 生物材料科学
- 传染性疾病 传染性疾病
背景情况:
- 由于抗生素耐药性,在医院获得的感染是全球性的威胁,需要新的治疗策略.
- 绿色纳米技术通过将环保方法与增强的治疗结果相结合,为开发新疗法提供了一种可持续的方法.
- 纳米结构酸 (HAP) 以其生物相容性和多孔结构而闻名,使其适用于治疗和再生应用.
研究的目的:
- 从鱼废物制造酸 (HAP) 纳米颗粒,并在其中封装黑米酒 (BRW) (HAP@BRW).
- 评估HAP@BRW纳米颗粒对病房感染的潜力,重点关注它们的抗微生物,抗菌膜和抗氧化剂特性.
- 评估HAP@BRW系统的生物相容性和药物输送能力,以对潜在的生物医学应用进行评估.
主要方法:
- 氧酸盐 (HAP) 纳米颗粒是使用废鱼 (红) 合成的.
- 黑米葡萄酒 (BRW) 被提取并封装在HAP纳米颗粒中,形成HAP@BRW.
- 描述包括光谱和显微镜分析;研究了药物释放动力学. 进行了抗微生物,抗菌膜,抗氧化剂和毒性 (体外和体内) 测试.
主要成果:
- HAP@BRW纳米颗粒表现出 BRW 的均封装,平均尺寸为 117.6 nm.
- 在24小时内观察到最大72%的BRW释放,这表明HAP作为药物输送系统的适用性.
- HAP@BRW证明了对MRSA,MSSA和Pseudomonas aeruginosa的强烈杀菌作用,并显著抑制了生物膜的形成. 它还显示出丰富的抗氧化特性和生物相容性.
结论:
- 来自可持续来源的HAP@BRW纳米颗粒显示出针对关键病原体的显著抗微生物和抗菌膜活性.
- 哈普纳米粒子系统促进了BRW有效的药物输送,具有良好的释放动力学.
- 由于其结合的特性,HAP@BRW是医疗植入物涂层的有希望的候选者,以预防植入物相关和医院感染.
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