在患有辐射诱导肠道病变的老鼠中,乌比奎诺的胃保护和微生物组调节作用
Walaa A Eraqi1, Walaa A El-Sabbagh2, Ramy K Aziz3,4
1Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt. walaa.eraqi@pharma.cu.edu.eg.
Animal microbiome
|July 19, 2024
概括
乌比金 (Ubq) 通过减少肠道损伤和恢复肠道细菌多样性,可以防止辐射肠炎. 这种抗氧化剂在减轻癌症患者放射治疗副作用方面表现有前途.
科学领域:
- 胃肠道学和辐射瘤学
- 微生物组研究 微生物组研究
- 抗氧化剂治疗药物 抗氧化剂治疗药物
背景情况:
- 辐射肠炎显著影响癌症患者的生活质量.
- 肠道微生物在肠道功能中的作用至关重要,但辐射的影响尚未完全理解.
- 乌比金 (Ubq) 是CoQ-10的减少形式,是一种强大的抗氧化剂,具有潜在的胃保护性质.
研究的目的:
- 调查乌比奎诺 (Ubq) 对辐射诱导肠炎的胃保护作用.
- 探索ubiquinol在辐射后调节肠道微生物群的潜力.
- 在大鼠模型中评估乌比奎诺对肠道组织,炎症标志物和肠道微生物多样性的影响.
主要方法:
- 雄性白色大鼠被分为控制,辐射 (IRR),Ubq_Post和Ubq_Pre/Post组.
- 辐射肠炎是使用急性7 Gy γ-辐射诱导的.
- 用16S rRNA测序分析了便微生物组;用组织病理学检查了肠道组织.
主要成果:
- 乌比金治疗减轻了辐射诱导的肠损伤,增强了再生和杯状细胞的表达.
- 在被辐射的老鼠中,乌比金使炎症标志物 (介素-1β,酶-3) 和氧化应激标志物正常化.
- 乌比金治疗恢复了肠道微生物的多样性,并重新调整了被辐射的老鼠的微生物组合,类似于对照水平.
结论:
- 乌比金显示出对辐射引起的肠炎具有显著的胃保护作用.
- 乌比金能有效地恢复肠道微生物群的多样性和辐射破坏的平衡.
- 乌比金为治疗辐射肠炎及其相关肠道失调症提供了一个有前途的治疗策略.
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