第七类原在乳腺癌扩散中的潜在作用
Sergio Pérez-Díaz1,2, Jessica Lindberg3,4, Luis Oliveros Anerillas3
1Department of Medical and Translational Biology, Umeå University, Umeå, SE-901 87, Sweden. sergio.perez.diaz@ki.se.
Cancer cell international
|July 19, 2024
概括
原VII (ColVII) 与乳腺癌细胞增殖和休眠的减少有关. 瘤中的高ColVII表达与积极的预后标记相关,表明其作为预测工具的潜力.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 生物化学 生化学
背景情况:
- 乳腺癌复发是一个重大的临床挑战,通常源于休眠的癌细胞.
- 了解乳腺癌休眠期的分子驱动因素对于制定预防复发策略至关重要.
- 细胞外矩阵 (ECM) 组件参与调节癌细胞行为,包括休眠状态.
研究的目的:
- 为了确定与缺氧诱导的乳腺癌休眠相关的ECM组件.
- 为了研究原VII (ColVII) 对乳腺癌细胞增殖的影响.
- 评估人类乳腺癌组织中ColVII表达与预后标志物的相关性.
主要方法:
- 在低氧诱导的休眠的MCF-7乳腺癌细胞中查ECM蛋白.
- 在实验室中评估MCF-7细胞增殖与重组ColVII.
- 使用3D球形培养的脂肪组织衍生的介质干细胞 (AdMSCs) 与MCF-7细胞共同培养以建模瘤微环境.
- 在临床乳腺癌样本中分析ColVII表达及其与预后标记的关联.
主要成果:
- 休眠的MCF-7细胞表现出增加的ColVII表达.
- 在ColVII培养的MCF-7细胞在体外表现出减少的增殖.
- 在3D球形体中,具有高ColVII表达的AdMSC与降低的MCF-7细胞增殖有关.
- 在人类乳腺癌组织中高的ColVII表达与有利的预后标志物相关,并且主要在肌皮细胞中发现.
结论:
- 科尔维因与乳腺癌细胞增殖的减少有关.
- 在肌上皮细胞中,ColVII的表达很高.
- 乳腺癌组织中的高ColVII表达作为一个积极的预后指标,表明其作为一种新的预后标记物的潜力.
相关概念视频
Fibril-associated Collagen
2.5K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
2.5K
Type IV Collagen of Basal Lamina
2.2K
Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
A type IV collagen molecule has six alpha chains which can...
2.2K
Collagens are the Major Structural Proteins of ECM
4.1K
Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
Connective tissue proper includes loose...
4.1K
Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
Phases of Wound Repair
5.9K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
5.9K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K


