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在消费者使用条件下,模拟包装干片剂型的湿度变化
1Department of Pharmaceutical Engineering, Kyungnam University, Changwon, South Korea.
Drug development and industrial pharmacy
|July 20, 2024
概括
一个数学模型预测了消费者使用期间干片的水分含量,有助于在使用中保质期 (ISL) 的确定. 该工具有助于确保产品质量,并指导存储管理,以延长产品的可行性.
科学领域:
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
- 食品科学 食品科学 食品科学
背景情况:
- 确定干燥固体产品的使用时保质期 (ISL) 对于保持质量至关重要.
- 消费者处理,涉及产品的移除,显著影响产品的内部水分水平.
- 现有的ISL确定方法往往缺乏精度,需要先进的预测工具.
研究的目的:
- 开发和验证一个数学模型,用于预测消费者使用期间干固体片中的水分含量.
- 建立一个以科学为基础的方法来准确地确定ISL.
- 为优化产品包装和管理策略提供一个工具.
主要方法:
- 开发了一个数学模型,集成产品水分吸附异温和包装水分传输.
- 包含一个质量平衡方程,计算包装中剩余的产品数量.
- 在各种环境条件下使用文献数据 (干燥剂容器) 和实验数据 (刷新糖果) 验证了该模型.
主要成果:
- 该模型在模拟的使用条件下准确地预测了干固体片中的水分含量.
- 对文献数据 (干燥剂) 和实验数据 (糖果) 的验证证实了模型的有效性.
- 该模型展示了在76%和90%相对湿度下预测湿度变化的能力.
结论:
- 开发的数学模型提供了一种可靠的方法,用于预测干固体产品在使用中的水分含量.
- 这种模型有助于准确,基于科学的在使用中的保质期 (ISL) 的确定,作为消费者指南.
- 该模型对于在整个产品生命周期中推产品管理方案非常有价值.
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