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种族化的经验,暴露的生物标志物和晚年认知:调解分析

Tara E Jenson^1,2, Kelly M Bakulski³, Linda Wesp⁴

¹Department of Environmental Health Sciences, Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, United States.

American journal of epidemiology

|July 20, 2024

概括

暴露于会导致老年人认知功能的种族差异. 解决环境不公正问题对于改善晚年认知和减少健康不平等至关重要.

科学领域:

环境健康环境健康
神经科学是一个神经科学.
公共卫生公共卫生

背景情况:

认知功能的种族差异在晚年仍然存在.
(Pb) 暴露是一种已知的神经毒剂,与不良健康结果有关.
系统性种族主义和环境不公正可能导致差异性暴露和认知健康.

研究的目的:

评估 (Pb) 暴露在老年人认知功能的种族差异中介作用.
研究环境不公正对认知健康结果的影响.
量化由暴露介导的种族认知关联的比例.

主要方法:

国家健康和营养和检查调查 (NHANES) 数据 (1999-2002,2011-2014) 的分析,包括1085名60岁以上的非西班牙裔黑人和2839名非西班牙裔白人参与者.
使用基于血液和人口统计数据的预测模型估计骨 (Pb).
使用数字符号替换测试 (DSST) 和全球认知测量来评估并发认知;使用回归系数进行调度分析.

主要成果:

据估计, (Pb) 暴露中介于种族和全球认知之间的关系的0.6%.
(Pb) 暴露介导了比赛与处理速度,注意力和工作记忆 (DSST) 之间的关联的4%.
连接系统性种族主义与认知差异的途径的很大一部分仍然无法通过暴露来解释.

结论:

由环境不公正驱动的可避免的暴露可能会影响后期认知健康的种族差异.
虽然暴露起作用,但系统性种族主义对认知差异的影响更广泛,但尚未定量.
针对减少和环境正义的公共卫生干预措施对于缓解认知不平等至关重要.

关键词:

老化的老化衰老的老化认知认知认知环境暴露环境暴露环境暴露环境的不公正环境的不公正流行病学方法流行病学方法暴露于的情况.调解分析调解分析种族群体是种族群体.

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