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Updated: Jun 20, 2025

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice
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与SCA44和SCAR13相关的GRM1突变通过不同的机制影响转基因谷氨酸受体1功能

Yuyang Wang1, Ashwin Muraleetharan1, Monica Langiu1

  • 1Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

British journal of pharmacology
|July 20, 2024
PubMed
概括

甲基胺基质受体1 (mGlu1) 突变会影响其在脊髓小脑缩症 (SCAs) 中的功能. 阿洛斯特基调节剂在罕见的SCA亚型中显示出恢复mGlu1功能的潜力.

关键词:
在 SCA4444 中,这是一个可怕的13 SCAR.通过全osteric 调制.谷氨酸酸盐是什么 谷氨酸酸盐甲基胺基甲基胺基受体的甲基胺基受体.自然发生的突变.神经药理学,脊髓大脑小骨动脉.

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