乳腺癌妇女的第二次原发性恶性瘤
Courtney Chen1, Joshua Tseng1, Farin Amersi1
1Department of Surgery, Cedars-Sinai Medical Center, Division of Surgical Oncology, Los Angeles, CA, USA.
Journal of surgical oncology
|July 20, 2024
概括
患有乳腺癌 (BC) 的女性患第二种原发性恶性瘤 (SPM) 的风险增加. 诸如家族病史和ER/PR阳性瘤等因素与BC幸存者的SPM发展有关.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 由于查和治疗的进步,人们注意到乳腺癌 (BC) 的生存率有所改善.
- 与一般人群相比,BC幸存者面临患第二次原发性恶性瘤 (SPM) 的风险较高.
- 关于在BC患者中导致SPM发展的因素的数据有限.
研究的目的:
- 确定与乳腺癌 (BC) 患者的第二次原发性恶性瘤 (SPM) 发展相关的临床病理和治疗特征.
- 分析一组BC幸存者的SPMs的类型和发病率.
- 了解以前被诊断患有BC的女性SPM的风险因素.
主要方法:
- 从1990年至2016年期望的单一机构数据库的回顾性审查.
- 分析了782名有BC病史的患者,重点研究了194名患有SPM的患者.
- 对临床病理学和治疗特征的评估.
主要成果:
- 在194名患有SPM的患者中,28.9%的年龄在50岁以下.
- 62.9%的人有恶性瘤家族史;11.3%的人有致病性遗传突变.
- 常见的SPM包括乳腺 (22%),黑色素瘤 (17.8%),妇科 (14.1%) 和结直肠 (12.6%). 大多数原发性乳腺瘤是ER/PR阳性的.
结论:
- 大多数患有SPM的BC患者都有ER/PR阳性瘤和恶性瘤家族史.
- 虽然化疗和放射能可以增加癌症风险,但它们与SPM的关联在这个队列中并非确定的.
- 结核病患者需要密切跟踪,因为他们更容易患上随后的恶性瘤.
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