素和睡眠障碍在α-synucleinopathies:一个系统的审查
Kausar Raheel1, Qi Rui See1, Veronica Munday1
1Sleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, De Crespigny Park, London, SE5 8AF, UK.
Current neurology and neuroscience reports
|July 20, 2024
概括
素系统的素系统.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 神经学 神经学
背景情况:
- 睡眠障碍是像帕金森病 (PD),勒维体痴呆症 (DLB) 和多重系统缩 (MSA) 这样的α-synucleinopathies中常见的非运动症状.
- 对于唤醒至关重要的素系统与睡眠调节有关,在这些疾病的动物模型中观察到它的调节障碍.
- 然而,素系统在人类α-synucleinopathies及其相关睡眠障碍中的确切作用仍然不清楚.
研究的目的:
- 系统地审查和批判性地评估当前证据,关于与阿尔法-同核蛋白病变中氧系统和睡眠障碍之间的关联.
- 确定现有研究中的研究差距和方法限制.
主要方法:
- 在PubMed,Web of Science和PsychINFO进行了系统的文献搜索.
- 包括在内调查素和快速眼动 (REM) 行为障碍 (RBD),PD,DLB和MSA中的睡眠.
- 搜索术语包括"α-synucleinopathies"",Orexin"和"睡眠障碍.
主要成果:
- 审查了17项研究:2项关于RBD,10项关于PD,4项关于DLB,1项关于MSA.
- 有证据表明,素水平可能会在RBD和PD早期阶段增加,并在后期阶段下降.
- 与对照组相比,在MSA患者中没有发现素水平的显著差异. 方法上的局限性阻碍了最终的结论.
结论:
- 在alpha-synucleinopathies中,有复杂的关系存在于orexinergic系统调节失调和睡眠障碍之间.
- 需要使用强大的方法进行进一步的研究,以阐明潜在的病理机制.
- 向素系统可能为这些神经退行性疾病中的运动和非运动症状提供治疗潜力.
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