加快的长期遗忘可能是与主观认知衰退相关的较高记忆投诉率的一个特征吗? 一个探索性研究
Marta Rodini1, Sabrina Bonarota2, Laura Serra2
1Department of Clinical Neuroscience and Neurorehabilitation, Laboratory of Neuropsychology of Memory, IRCSS Santa Lucia Foundation, Rome, Italy.
Journal of Alzheimer's disease : JAD
|July 20, 2024
概括
主观认知衰退 (SCD) 可能表明未来的阿尔茨海默病 (AD). 加快的长期遗忘,特别是在严重的SCD病例中,表明AD风险的潜在早期检测工具.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 老年学是一门学科.
背景情况:
- 主观认知衰退 (SCD) 被认为是未来阿尔茨海默病 (AD) 的潜在早期指标.
- 调查SCD的认知标志物对于早期AD检测和干预策略至关重要.
研究的目的:
- 要确定加速长期遗忘 (ALF) 是否是SCD的认知特征.
- 使用MRI探索与SCD患者的ALF相关的潜在大脑区域.
主要方法:
- 招募了31名SCD患者 (18名轻度,13名重度) 和16名健康对照 (HC).
- 用口头和视觉空间任务进行了长期忘记程序,多次延迟 (即时,30分钟,24小时,7天).
- 进行探索性MRI分析,以评估与记忆相关的皮质网络中的功能连接.
主要成果:
- 在标准测试或即时回忆中没有发现群体之间的显著差异.
- 与HC相比,严重的SCD个体表现出明显更大的口头长期遗忘,特别是在24小时和7天间隔.
- 默认模式中的功能连接性,突出性和前端-双侧网络与SCD组的口头长期记忆性能相关.
结论:
- 长期遗忘评估可以作为识别SCD记忆障碍的敏感工具.
- 这种方法可以帮助早期检测患有阿尔茨海默病风险的个体.
- 对ALF及其神经相关的进一步研究可以完善早期AD诊断方法.
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