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Updated: Aug 5, 2026

Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
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MTR3D-AF2:使用AlphaFold2在人类蛋白质组中扩大空间衍生误解耐受性得分的覆盖范围

Aaron S Kovacs1, Stephanie Portelli1,2, Michael Silk3,4

  • 1The Australian Center for Ecogenomics, School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.

Protein science : a publication of the Protein Society
|July 20, 2024
PubMed
概括

使用AlphaFold2模型增强了误解耐受率 (MTR),以创建MTR3D-AF2.2. 这种新工具显著改善了人类蛋白质组中有害基因变异的识别.

关键词:
误解突变是一种错误的突变.病原性预测 病原性预测人口变化的变化.蛋白质结构预测 蛋白质结构预测选择性的压力选择性压力.

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相关概念视频

Protein Folding01:22

Protein Folding

Overview
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...