月经周期驱动的激素度与白色和灰色物质的结构变化一起波动,在整个大脑中发生变化
Elizabeth J Rizor1,2, Viktoriya Babenko1,3, Neil M Dundon1,2,4
1Department of Psychological & Brain Sciences, University of California, Santa Barbara, California, USA.
Human brain mapping
|July 20, 2024
概括
月经周期期间的荷尔蒙波动会改变大脑结构,影响白质和皮质厚度. 这些变化发生在整个大脑中,影响各种功能系统.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 人体生理学 人体生理学
背景情况:
- 下垂体-垂体-腺 (HPG) 轴调节生殖功能,影响行为和生理学.
- 已知周期性荷尔蒙波动会影响中枢神经系统,但它们对大脑结构的影响在很大程度上仍未被描述.
- 了解这些结构变化对于理解HPG轴激素效应的全部范围至关重要.
研究的目的:
- 研究月经周期激素度与人类大脑结构变化之间的关系.
- 检查不同月经周期阶段白质 (WM) 微观结构,皮质厚度 (CT) 和大脑体积的变化.
- 为了确定受这些荷尔蒙波动影响的特定大脑区域和途径.
主要方法:
- 使用多维扩散和T1权重磁共振成像 (MRI) 对30名自然骑自行车的女性.
- 在三个估计的月经周期阶段收集的成像数据:月经,排卵和半月期.
- 与定量MRI测量相关的HPG轴激素水平 (17β-雌激醇,LH,FSH,孕激素) (例如,扩散异性质,平均扩散性,CT,组织/CSF体积).
主要成果:
- 17β-雌激醇和黄素激素 (LH) 度与大脑范围内的白质扩散异性质 (μFA) 有正相关.
- 毛囊刺激激素 (FSH) 与大脑的皮层厚度 (CT) 有积极的相关性.
- 孕激素与组织体积增加和脑脊液 (CSF) 体积减少有关,而总脑体积保持稳定.
- 在特定区域,特别是叶和叶,FSH和孕激素与平均扩散率 (Diso) 和CT有相反的关系.
结论:
- 这项研究首次证实了与月经周期荷尔蒙节奏相关的白质微观结构和皮质厚度在整个大脑的同时发生的变化.
- 荷尔蒙波动对已知HPG轴受体区域 (例如,中间叶,前额皮层) 和其他区域的大脑结构产生影响.
- 这些发现表明,HPG轴激素在整个月经周期中,在多个叶片和功能系统中显著影响大脑结构.
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