通过加入基于异索基的聚碳酸盐,提高了烯复合材料的可降解性
Jorge San Jacinto Garcia1, Natalia Sanz Del Olmo1, Daniel J Hutchinson1
1Royal Institute of Technology, School of Chemical Science and Engineering, Department of Fibre and Polymer Technology, KTH, Teknikringen 56-58, 100 44 Stockholm, Sweden.
ACS applied materials & interfaces
|July 20, 2024
概括
研究人员开发了一种新的可降解骨复合物,使用基功能化聚碳酸盐. 改性材料显示增强的水解和保持机械强度,为骨折固定提供了一个有前途的替代方案.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 整形外科手术 整形外科手术
背景情况:
- 目前用于断裂固定的金属板和螺丝缺乏定制性和可降解性.
- 使用1,3,5-triazine-2,4,6-trione (TATO) 单体的含有氧酸盐的复合材料显示出有前途,但缺乏可降解性.
- 开发可降解的替代品对于改善骨折修复至关重要.
研究的目的:
- 为了提高TATO基复合材料的可降解性,用于骨折固定.
- 为了评估以基功能化异化基聚碳酸盐 (aPC) 对复合材料性能的影响.
- 评估改性复合材料的机械性能和生物相容性.
主要方法:
- 合成了三种基功能化聚碳酸盐 (aPC1,aPC2,aPC3) 具有不同的基位置.
- 配制的复合材料含有1,3和5重%的aPCs和基功能化聚烯酸 (aPCL) 作为对照.
- 评估了机械性能,吸水,水解降解 (在PBS中) 和细胞毒性.
主要成果:
- 与整洁复合材料相比,5%重量的aPC3配方在8周后的降解率增加了469%.
- 这种配方在模块上显示了28%的适度下降,保持了4.01 GPa的刚度.
- 有aPC3的复合材料与合成骨模型中整洁复合材料的曲刚度和强度相匹配或超过.
结论:
- 以基功能化异化基聚碳酸盐,特别是aPC3,显著增强了TATO复合材料的水解降解.
- 经过修改的复合材料保持了有利的机械性能,适用于骨折修复.
- aPC3是一种有前途的添加剂,用于制造硬,可降解的复合材料,用于长期治疗骨折.
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