在这项研究中,表现不当和自闭症谱系障碍是为了探索早期发育
Yitian Zhang1,2, Michelle T Delahanty2, Stephanie M Engel2
1Epidemiology and Database Studies, Real World Solutions, IQVIA Inc, Durham, USA.
Paediatric and perinatal epidemiology
|July 20, 2024
概括
出生时具有非顶部呈现 (错误呈现) 的婴儿患自闭症谱系障碍 (ASD) 的几率更高. 对这些儿童的早期监测可以改善发展支持和结果.
科学领域:
- 新生儿发育的新生儿发展
- 神经发育障碍 神经发育障碍
- 产科 产科 产科 产科 产科
背景情况:
- 婴儿出生时的表现可以表明发育差异.
- 非顶部呈现 (错误呈现) 与并发症和神经发育延迟有关,包括自闭症谱系障碍 (ASD).
- 关于表现不当与ASD相关性的研究有限.
研究的目的:
- 调查分娩时表现不当和ASD之间的关联.
- 要确定妊娠年龄是否会改变这种关联.
主要方法:
- 利用了研究探索早期发育 (SEED) 的数据,这是一项多个地点的病例控制研究.
- 定义错误呈现为非顶部呈现,分类为后和其他类型.
- 采用多变量逻辑回归来分析表达错误与ASD之间的关联.
主要成果:
- 包括4047名参与者 (1873名患有自闭症,2174名对照).
- 呈现错误与ASD的几率增加有关 (aOR1.31,95% CI1.02-1.68),经过调整以考虑混因素.
- 这种关联在错误表现类型和妊娠年龄之间是一致的.
结论:
- 在分娩时出现错误的表现显示了与ASD的温和联系.
- 建议对有缺陷表现的婴儿进行早期神经发育监测,以促进及时识别和支持ASD.
- 通过早期干预优化ASD儿童的发展结果.
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