长非编码RNAH19在人类肺癌中的新兴作用
Irfan Ahmad1, Saade Abdalkareem Jasim2, Klunko Nataliya Sergeevna3
1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Cell biochemistry and function
|July 20, 2024
概括
肺癌是全球癌症死亡的主要原因之一. 本综述探讨了长时间非编码RNA H19 (lncRNA H19) 如何促进肺癌的进展和对治疗的耐药性,提供了新的诊断和治疗见解.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 肺癌是全球癌症死亡的主要原因,其5年生存率很低,通常是由于晚期诊断.
- 非小细胞肺癌 (NSCLC) 占病例的80-85%,通过了解瘤驱动因素来治疗.
- 长非编码RNAs (lncRNAs) 是细胞过程的关键调节者; lncRNA H19 在瘤中经常过度表达.
研究的目的:
- 审查肺癌中 lncRNA H19 的异常过度表达.
- 阐明IncRNA H19驱动肺癌进展的分子途径.
- 突出 lncRNA H19 在肺癌诊断和治疗中的潜力.
主要方法:
- 关于lncRNA H19和肺癌的研究的文献综述.
- 在瘤发生过程中涉及IncRNA H19的分子机制的分析.
- 综合了关于lncRNA H19在入侵,迁移,转移和治疗耐药性方面的发现.
主要成果:
- 在包括肺癌在内的各种癌症中,IncRNA H19显著过度表达.
- lncRNA H19促进细胞生长,入侵,迁移,上皮细胞-介质细胞过渡和转移.
- 增加的lncRNA H19表达与肺癌模型中的治疗耐药性有关.
结论:
- lncRNA H19是肺癌发展和进展的关键瘤原因子.
- 向IncRNA H19为新型肺癌诊断和治疗提供了一个有前途的战略.
- 对lncRNA H19机制的进一步研究可以打开对抗肺癌的新途径.
相关概念视频
02:39lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
03:18Non-LTR Retrotransposons
11.4K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.4K
01:12Loss of Tumor Suppressor Gene Functions
4.8K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
4.8K
01:22MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
01:20Types of RNA
5.7K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
5.7K