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Updated: Jun 20, 2025

A High-throughput-compatible FRET-based Platform for Identification and Characterization of Botulinum Neurotoxin Light Chain Modulators
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基于模型的A型肉毒神经毒素对肌肉收缩抑制的跨物种解释

Hyo-Jeong Ryu1,2, Seongsung Kwak1, Misun Park1

  • 1Department of Pharmacology and Toxicology, Gwangyo R&D Center, Medytox Inc., Suwon, South Korea.

Biopharmaceutics & drug disposition
|July 20, 2024
PubMed
概括

这项研究开发了一种动力学 - 药理学 (K-PD) 模型,用于分析来自动物上毒神经毒素A型 (BoNT/A) 研究的肌肉反应数据. 该模型有助于预测BoNT/A效应,并将动物数据与人类反应联系起来.

关键词:
肉毒神经毒素A型的神经毒素动力-药理动力学 (K-PD) 模型肌肉收缩的抑制 抑制肌肉收缩药理动力学上的药理动力学药物动力学 药物动力学

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