在Peromyscus小鼠的雄性生殖道中的交配系统变异和基因表达
Erin R Voss1, Michael W Nachman1
1Department of Integrative Biology and Museum of Vertebrate Zoology, University of California, Berkeley, Berkeley, California, USA.
Molecular ecology
|July 20, 2024
概括
后性选择 (PCSS) 推动了繁殖中的快速基因进化. 这项研究揭示了交配系统显著改变生殖道基因表达,特别是在精液囊中,影响男性的生殖成功.
科学领域:
- 进化生物学 进化生物学
- 基因组学就是基因组学.
- 生殖生物学 生殖生物学
背景情况:
- 结合后性选择 (PCSS) 推动了基因的快速进化,但它对基因表达的影响还没有得到充分探索.
- 大多数研究都集中在丸上,忽视了男性生殖成功的其他生殖组织.
研究的目的:
- 调查交配系统变异对Peromyscus小鼠自然种群生殖道基因表达的影响.
- 识别与交配系统相关的基因并检查它们的进化历史.
主要方法:
- 丸,精液囊泡,上皮和肝脏的RNA测序来自雄性P. californicus (一夫多妻),P. boylii和P. maniculatus (多夫多妻).
- 差异基因表达分析以识别交配系统相关的差异表达基因 (MS-DEGs).
- 使用已发表的动物基因组对Peromyscus表达基因的积极和放松选择的分析.
主要成果:
- 鉴定了3627个MS-DEGs,表达的转移与P.californicus相对于P.maniculatus和P.boylii之间一致.
- 精液囊泡显示出与交配行为最强烈的关联,89%的差异表达基因是MS-DEGs,包括Svs2和Pate4.
- 203个MS-DEG表现出积极选择的证据;14个繁殖基因显示出全树的积极选择和一夫一妻制物种的融合放松选择.
结论:
- 交配系统的变异显著影响男性生殖道的基因表达,特别是精子囊泡.
- 基因表达和序列进化的变化表明适应性反应对性选择强度影响精子特征和交配插头.
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