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通过对DNAJC1010进行上调,MCM8促进了肺癌的进展

Lei Cao¹, Hongsheng Liu¹, Zhijun Han¹

¹Department of Thoracic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Journal of cellular and molecular medicine

|July 20, 2024

概括

高MCM8 (微小染色体维护8) 表达驱动肺癌 (LC) 的进展和转移通过调节DNAJC10. 这个MCM8/DNAJC10轴为LC患者提供了潜在的治疗目标和诊断生物标志物.

科学领域:

分子生物学分子生物学
在瘤学瘤学.
遗传学遗传学是一个

背景情况:

微小染色体维护8 (MCM8) 是一种参与DNA复制和瘤发生的螺旋酶.
在包括肺癌 (LC) 在内的各种人类癌症中,MCM8的升级调节,但其在LC进展中的作用尚不清楚.

研究的目的:

研究MCM8在肺癌发展中的功能和机制.
确定肺癌的潜在治疗点和诊断生物标志物.

主要方法:

在LC细胞和组织中分析MCM8表达.
在体外和体内实验中涉及MCM8敲击和过度表达的实验.
基因阵列和共同免疫沉 (CO-IP) 测试以确定MCM8标.
对癌症基因组图谱 (TCGA) 数据库对MCM8和DNAJC10相关性的分析.

主要成果:

在LC中MCM8的表达很高,并与晚期瘤,转移和不良预后相关.
MCM8的淘汰抑制了LC细胞的生长和迁移;MCM8的过度表达促进了细胞周期的进展,迁移,增殖和亡.
DNAJC10被确定为MCM8的下游目标,调解其致癌效应.
在LC中,MCM8和DNAJC10表达呈正相关性,DNAJC10上调也与生存率差相关.

结论:

MCM8/DNAJC10轴在肺癌的发展中起着至关重要的作用.
MCM8和DNAJC10代表了肺癌的潜在治疗点和诊断生物标志物.

关键词:

在DNAJC10中使用.在MCMM8中,MCMM8是MCMM8.细胞的增殖细胞的增殖.肺癌是一种肺癌.移民移民迁移迁移

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