中性粒细胞与淋巴细胞的比率以及帕金森病的纵向认知表现
Jenniffer Lucero1,2, Ashita Gurnani1, Janice Weinberg3
1Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, 02118, USA.
Annals of clinical and translational neurology
|July 20, 2024
概括
中性粒细胞与淋巴细胞比率 (NLR) 的升高与帕金森病 (PD) 患者的认知表现较差有关,但与五年内轻度认知障碍 (MCI) 的发展无关.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 老年学是一门学科.
背景情况:
- 周围炎症与一般和帕金森病 (PD) 患者的认知衰退有关.
- 中性粒细胞与淋巴细胞的比率 (NLR) 是系统性炎症的标志物.
研究的目的:
- 在患有PD的个体中调查NLR,认知表现和轻度认知障碍 (MCI) 之间的关联.
- 为了确定NLR是否在5年内预测PD的认知衰退.
主要方法:
- 在5年内对来自帕金森病进展标记计划 (PPMI) 的422名PD参与者的回顾性分析.
- 使用蒙特利尔认知评估 (MoCA) 和其他神经心理测试评估认知功能.
- 混合效应回归模型分析了NLR和认知结果之间的关联,控制共变量.
主要成果:
- 在NLR和MoCA得分之间发现了负相关性 (p=0.033).
- 较高的NLR与所有评估领域的更快的认知衰退和更差的表现相关.
- 在5年的随访期间,NLR与MCI状态没有显著的关联.
结论:
- 升高的NLR与PD患者的认知能力下降有关.
- NLR可能反映了认知功能的日常波动,而不是PD中MCI的进展.
- 需要在不同的队列中进行进一步的研究来证实这些发现.
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