消化管串测试在患有eosinophilic消化管炎的儿童中的利用和影响:一年的经验
Laura A Quinn1, Rachel Andrews1, Maureen Bauer2
1Digestive Health Institute, Children's Hospital Colorado, Gastrointestinal Eosinophilic Diseases Program, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine, Aurora, Colorado, USA.
Journal of pediatric gastroenterology and nutrition
|July 20, 2024
概括
食道串测试 (EST) 能够有效地监测儿童的性食道炎 (EoE),在没有内镜的情况下指导治疗. 这种最少的侵入性工具在现实世界使用中显示出高的完成率和耐受率.
科学领域:
- 胃肠病学 胃肠病学
- 儿科过敏和免疫学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 性食道炎 (EOE) 需要持续监测疾病活动.
- 对于儿科患者来说,EoE监测的内镜程序可能是繁重的.
- 至少侵入性诊断工具是必要的,以有效地管理 EoE.
研究的目的:
- 评价一小时食道串测试 (EST) 在儿科EoE护理中的实际利用和影响.
- 评估EST在儿科队列中的可行性,耐受性和临床实用性.
- 确定 EST 发现如何影响患有 EoE 的儿童的治疗决策.
主要方法:
- 在12/1/2022和11/30/2023之间进行的39个成功的食道串测试 (ESTs) 的回顾性审查.
- 分析患者人口统计数据,EST完成率,不良事件和试验失败的原因.
- 评估EST在指导儿童性食道炎 (EoE) 治疗决策中的作用.
主要成果:
- 在45次尝试中,在31名儿科患者中成功完成了39次EST (87%的完成率).
- 在95%的病例中,EST在没有内镜的情况下促进了EoE评估.
- 根据EST结果进行了治疗调整,该结果表明活跃的 (38.5%) 或不活跃的 (61.5%) 疾病.
结论:
- 食道串测试 (EST) 是一种耐受性良好且侵袭性最小的工具,用于监测儿童的性食道炎 (EoE) 疾病活性.
- EST为指导治疗策略提供了有价值的数据,减少了重复内镜检查的需要.
- 现实世界的数据支持EST在儿科EOE的常规管理中的实用性.
相关概念视频
Esophageal Strictures-I: Introduction
79
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
79
Esophageal Strictures-II: Clinical Features and Management
61
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
61
Barrett Esophagus-II: Clinical Manifestations and Management
135
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
135
Gastroesophageal Reflux Disease II: Clinical Features and Management
68
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
68
Barrett Esophagus-I: Introduction
80
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
80
Endoscopic Procedures I: Esophagogastroduodenoscopy
88
An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:
During an EGD, the endoscope can be used to:
88


