免疫基因调节与非人类灵长类动物的年龄和环境逆境有关
Marina M Watowich1,2,3,4, Christina E Costa5,6, Kenneth L Chiou2,3
1Department of Biology, University of Washington, Seattle, Washington, USA.
Molecular ecology
|July 20, 2024
概括
环境逆境,如风,可以影响分子衰老路径,特别是在基因调节. 这项对 rhesus 的研究揭示了时间老龄化和环境挑战之间的共同和独特的表观遗传特征.
科学领域:
- 表观遗传学和衰老研究.
- 进行比较的基因组学.
- 环境毒理学环境毒理学
背景情况:
- 现型衰老在哺乳动物中很常见,这意味着共享的衰老机制.
- 衰老与DNA甲基化和基因表达的分子变化有关.
- 环境因素可以影响与年龄相关的分子变化,但它们与主要衰老途径的重叠是不清楚的.
研究的目的:
- 调查环境不利因素是否通过与时间老化相同的分子途径影响基因调节.
- 在自由散居的 rhesus macaques 的自然主义种群中,描述分子衰老,特别是 CpG 甲基化.
- 将衰老的表观遗传特征与由重大环境挑战 (风) 引起的表观遗传特征进行比较.
主要方法:
- 在571个样本中分析了CpG甲基化模式,这些样本来自499只自由散居的 rhesus macaques.
- 甲基化位点与时间表年龄的统计联系.
- 在研究期间,确定与暴露于主要风相关的甲基化部位.
主要成果:
- 在78,661个CpG位点 (31%的测试位点) 上,年龄与甲基化显著相关.
- 与年龄相关的甲基化变化在基因调节区域和免疫细胞活性较低的区域显示出不同的模式.
- 32,048个CpG地点与风暴露有显著的关联,与与年龄相关的地点重叠,特别是在监管区域.
结论:
- 环境不利因素可能会导致活跃转录的基因区域中与衰老相关的分子表型.
- 初级衰老表现出明显的表观遗传特征,特别是在非监管区域.
- 在衰老过程中,表观遗传稳定似乎以协调,多层次的方式丧失.
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